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Look Better Naked: Learn more about injectable fillers Restylane and Perlane

Editor’s note: This is the second of a four-part series on injectable fillers. To read the first part on Juvederm Ultra and Ultra-Plus, click HERE.

Restylane and Perlane, made by Medicis Aesthetics, known also now as Restylane-L and Perlane-L (with lidocaine added), are clear gel formulations of hyaluronic acid.

The difference from Juvederm is the lack of the Hylacross technology, which some studies have shown causes Juvederm to last longer.

Expect a syringe of Restylane or Perlane to last six months to nine months. It will last much longer, up to 18 months, if you add more to the area at the four- to six-month mark.

What makes Perlane different is the average size of the particles and the depth of injection. On average, the gel particles in Perlane are larger than those in Restylane, which makes Perlane a good choice for wrinkles that benefit from a deeper injection into the skin. Your doctor will be the one to decide which one is more appropriate for the areas you want treated.

The cost of Restylane varies between rock bottom specials you occasionally see for $300 per syringe to $650, and Perlane from $450 to $700 per syringe.

One really nice thing about the hyaluronic acid fillers is that they can be quickly and easily dissolved by injecting an enzyme called Hyaluronidase. So, if the filler ends up in an area you didn’t want it or you decide you don’t like the look afterwards, you can dissolve it!

This is also a good safety back-up plan so I will tend to use hyaluronics whenever I’m injecting in a more delicate area, such as under the eyes. I also recommend hyaluronics for anyone who is a filler “virgin.” It’s a great way to introduce a brand new patient to the effects of fillers because it’s completely reversible.

The Hyaluronic Acid family of products are generally biocompatible, which means allergy skin testing is not required prior to treatment. They are derived from bacteria, and should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram-positive bacteria; by people with previous bad allergies to drugs who have required in-hospital treatment; or by people with bleeding disorders.

None of the fillers containing lidocaine should be used by people with a known allergy to lidocaine.

Darren A. Farnesi, M.D., APC, offers his sound advice and personal knowledge of the industry as a successful doctor with Medical Age Management Inc. He can be reached at (619) 299-0700 or online at his website.